Publication

Álvaro F. Fernández, Salwa Sebti, Yongjie Wei, Zhongju Zou, Mingjun Shi, Kathryn McMillan, Congcong He, Tabitha Ting, Yang Liu, Wei-Chung Chiang, Denise Marciano, Gabriele Schiatarella, Govind Bhagat, Orson W. Moe, Ming-Chang Hu and Beth Levine. Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice.Disruption of the beclin 1/Bcl-2 autophagy regulatory complex promotes longevity in mice. Nature. 558 (7708) 136-140 (2018).

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Wei-Chung Chiang, Yongjie Wei, Yi-Chun Kuo, Shuguang Wei, Anwu Zhou, Zhongju Zou, Jenna Yehl, Matthew J. Ranaghan, Adam Skepner, Joshua A. Bittker, Jose R. Perez, Bruce A. Posner and Beth Levine. High Throughput Screens to Identify Autophagy Inducers that Function by Disrupting Beclin 1/Bcl-2 Binding. ACS Chem Biol. (2018). doi: 10.1021/acschembio.8b00421.

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Yongjie Wei*, Wei-Chung Chiang*, Rhea Sumpter Jr., Prashant Mishra and Beth Levine. Prohibitin 2 is an Inner Mitochondrial Membrane Mitophagy Receptor. Cell. 168(1-2) 224-238 (2017). (*co-first author)

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Wei-Chung Chiang, Tsui-Ting Ching, Hee-Chul Lee, Carol Mousigian and Ao-Llin Hsu. HSF-1 regulators DDL-1/2 link insulin-like signaling to heat-shock responses and modulation of longevity. Cell. 148(1) 322-334 (2012).

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Wei-Chung Chiang, Daniel X. Tishkoff, Bo Yang, Joshua Wilson-Grady, Xiaokun Yu, Travis Mazer, Mark Eckersdorff, Steven P. Gygi, David B. Lombard, and Ao-Lin Hsu. C. elegans SIRT6/7 Homolog SIR-2.4 Promotes DAF-16 Relocalization and Function during Stress. PLoS Genetics, 8(9): e1002948.

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Tsui-Ting Ching, Wei-Chung Chiang, Ching-Shih Chen and Ao-Lin Hsu. Celecoxib Extends Worm Lifespan Independent of COX-2 Inhibition. Aging Cell. 10(3):506-19 (2010).

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Mu-Hwa Yang, Wei-Chung Chiang, Shyue-Yih Chang, Po-Min Chen and Kou-Juey Wu. Increased NBS1 expression as a prognostic marker of aggressive head and neck cancer and overexpression of NBS1 contributes to transformation. Clin. Cancer Res. 12, 507-515 (2006).

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Yen-Chung Chen, Yi-Ning Su, Po-Chien Chou, Wei-Chung Chiang, Ming-Cheng Chang, Liang-Shun Wang, Shu-Chun Teng and Kou-Juey Wu. Overexpression of NBS1 contributes to transformation through the activation of phosphatidylinositol 3-kinase/Akt. J. Biol. Chem. 280, 32505-11 (2005).

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Shih-Hung Yu, Wei-Chung Chiang, Hsiu-Ming Shih and Kou-Juey Wu. Stimulation of c-Rel transcriptional activity by PKA catalytic subunit beta. J. Mol. Med. 82(9):621-8 (2004).